For research use only. Not for therapeutic Use.
DHPG (Cat No.:M099289), often used as (S)-3,5-dihydroxyphenylglycine, is a selective agonist of group I metabotropic glutamate receptors (mGluR1 and mGluR5). It is widely applied in neuroscience research to study excitatory neurotransmission, synaptic plasticity, and signaling pathways linked to learning and memory. By activating mGluRs, DHPG induces long-term potentiation (LTP) and long-term depression (LTD) in hippocampal neurons, making it a critical tool for investigating mechanisms of synaptic modulation. Its ability to mimic glutamatergic activity supports exploration of neurological disorders, including epilepsy, Alzheimer’s disease, and neurodegeneration.
| CAS Number | 146255-66-5 |
| Synonyms | 2-amino-2-(3,5-dihydroxyphenyl)acetic acid |
| Molecular Formula | C8H9NO4 |
| Purity | ≥95% |
| IUPAC Name | 2-amino-2-(3,5-dihydroxyphenyl)acetic acid |
| InChI | InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13) |
| InChIKey | HOOWCUZPEFNHDT-UHFFFAOYSA-N |
| SMILES | C1=C(C=C(C=C1O)O)C(C(=O)O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
