DHODH-IN-17

• CAT Number: M134579
• CAS Number: 16344-26-6
• Molecular Formula: C12H9ClN2O2
• Molecular Weight: 248.67
• Purity: ≥95%
• Synonyms: 2-(4-chloroanilino)pyridine-3-carboxylic acid
• InChI: InChI=1S/C12H9ClN2O2/c13-8-3-5-9(6-4-8)15-11-10(12(16)17)2-1-7-14-11/h1-7H,(H,14,15)(H,16,17)
• InChIKey: YEXIXVLEDGNAKM-UHFFFAOYSA-N
• SMILES: C1=CC(=C(N=C1)NC2=CC=C(C=C2)Cl)C(=O)O

DHODH-IN-17（Cat No.:M134579）is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH), a mitochondrial enzyme essential for de novo pyrimidine biosynthesis. By targeting DHODH, this compound disrupts nucleotide synthesis, leading to cell cycle arrest and apoptosis, particularly in rapidly proliferating cells such as cancer or activated immune cells. DHODH-IN-17 has demonstrated strong antiproliferative effects in preclinical cancer and autoimmune disease models. It is a valuable tool for studying metabolic vulnerabilities in disease, exploring immunomodulatory strategies, and developing targeted therapies involving pyrimidine metabolism and mitochondrial function.