For research use only. Not for therapeutic Use.
DHODH-IN-16（Cat No.:I044437）is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH), a mitochondrial enzyme essential for de novo pyrimidine biosynthesis. By blocking DHODH activity, DHODH-IN-16 depletes intracellular pyrimidine pools, leading to impaired DNA and RNA synthesis, particularly in rapidly proliferating cells such as cancer cells and activated lymphocytes. It has demonstrated anticancer and immunosuppressive potential in preclinical studies, showing efficacy in models of leukemia, autoimmune diseases, and viral infections. DHODH-IN-16 is a valuable tool for exploring nucleotide metabolism and developing targeted therapies for proliferative and immune-driven disorders.
| CAS Number | 2511248-11-4 |
| Synonyms | 6-[4-ethyl-3-(hydroxymethyl)-5-oxo-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-propan-2-ylisoquinolin-1-one |
| Molecular Formula | C24H25FN4O3 |
| Purity | ≥95% |
| IUPAC Name | 6-[4-ethyl-3-(hydroxymethyl)-5-oxo-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-propan-2-ylisoquinolin-1-one |
| InChI | InChI=1S/C24H25FN4O3/c1-5-27-22(13-30)26-29(24(27)32)21-11-16-17(10-19(21)25)23(31)28(12-18(16)14(2)3)20-9-7-6-8-15(20)4/h6-12,14,30H,5,13H2,1-4H3 |
| InChIKey | BZKHQYHQHLKJNX-UHFFFAOYSA-N |
| SMILES | CCN1C(=NN(C1=O)C2=C(C=C3C(=C2)C(=CN(C3=O)C4=CC=CC=C4C)C(C)C)F)CO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
