DGK-IN-1

• CAT Number: I044507
• CAS Number: 2407892-34-4
• Molecular Formula: C29H27Cl2N5O
• Molecular Weight: 532.46
• Purity: ≥95%
• Synonyms: 8-[(2S,5R)-4-[bis(4-chlorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-1,5-naphthyridine-2-carbonitrile
• InChI: InChI=1S/C29H27Cl2N5O/c1-18-17-36(29(20-4-8-22(30)9-5-20)21-6-10-23(31)11-7-21)19(2)16-35(18)26-14-27(37)34(3)25-13-12-24(15-32)33-28(25)26/h4-14,18-19,29H,16-17H2,1-3H3/t18-,19+/m0/s1
• InChIKey: REURPYMYAHZMMX-RBUKOAKNSA-N
• SMILES: C[C@@H]1CN([C@H](CN1C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl)C)C4=CC(=O)N(C5=C4N=C(C=C5)C#N)C

DGK-IN-1（Cat No.:I044507）is a selective small-molecule inhibitor of diacylglycerol kinase (DGK), an enzyme responsible for converting diacylglycerol (DAG) into phosphatidic acid (PA), thereby regulating key signaling pathways involved in cell proliferation, differentiation, and immune responses. By inhibiting DGK, DGK-IN-1 elevates intracellular DAG levels, enhancing the activation of protein kinase C (PKC) and other downstream effectors. It is used in immunology and cancer research to explore the modulation of T-cell activation and tumor immunity. DGK-IN-1 serves as a valuable tool in studying lipid signaling and potential therapeutic strategies targeting immune modulation.