For research use only. Not for therapeutic Use.
DFP00173(CAT: I017620) is a potent and selective aquaporin-3 (AQP3) inhibitor, showing activity against both mouse and human AQP3 with IC₅₀ values of ~0.1–0.4 μM. It demonstrates strong selectivity for AQP3 over closely related aquaporin isoforms AQP7 and AQP9, making it an excellent probe for dissecting isoform-specific functions. DFP00173 effectively inhibits glycerol permeability in human erythrocytes (IC₅₀ ≈ 0.2 μM), highlighting its role in regulating glycerol transport across membranes. This compound is a valuable research tool for exploring aquaporin biology, metabolic regulation, skin hydration, and potential therapeutic strategies targeting AQP3-related disorders, including cancer and metabolic disease.
| CAS Number | 672286-03-2 |
| Synonyms | 1-(2,6-dichlorophenyl)-3-(5-nitrothiophen-3-yl)urea |
| Molecular Formula | C11H7Cl2N3O3S |
| Purity | ≥95% |
| IUPAC Name | 1-(2,6-dichlorophenyl)-3-(5-nitrothiophen-3-yl)urea |
| InChI | InChI=1S/C11H7Cl2N3O3S/c12-7-2-1-3-8(13)10(7)15-11(17)14-6-4-9(16(18)19)20-5-6/h1-5H,(H2,14,15,17) |
| InChIKey | AATXXTHMITUAOJ-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)Cl)NC(=O)NC2=CSC(=C2)[N+](=O)[O-])Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
