Dexamethasone 21-phosphate disodium salt

• CAT Number: R065701
• CAS Number: 2392-39-4
• Molecular Formula: C22H28FNa2O8P
• Molecular Weight: 516.41
• Purity: ≥95%
• Synonyms: (11β,16α)-9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-pregna-1,4-diene-3,20-dione, disodium salt
• Target: Vitamin D Related/Nuclear Receptor
• Storage: -20°C
• IUPAC Name: disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
• InChI: InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
• InChIKey: PLCQGRYPOISRTQ-FCJDYXGNSA-L
• SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

Dexamethasone 21-phosphate disodium salt（Cat No.:R065701）is a water-soluble derivative of dexamethasone, a potent synthetic glucocorticoid. The phosphate group at the 21-position enhances solubility, making it suitable for intravenous and intramuscular administration. It exerts strong anti-inflammatory, immunosuppressive, and anti-allergic effects by binding to glucocorticoid receptors and modulating gene expression. This form is commonly used in acute medical settings to treat conditions such as severe allergic reactions, cerebral edema, autoimmune diseases, and certain cancers. Its rapid onset and high potency make it valuable in emergency care and controlled therapeutic regimens.