Desthiobiotin-PEG4-propargyl

• CAT Number: I044716
• CAS Number: 1951424-89-7
• Molecular Formula: C21H37N3O6
• Molecular Weight: 427.53
• Purity: ≥95%
• Synonyms: 6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]-N-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]hexanamide
• InChI: InChI=1S/C21H37N3O6/c1-3-10-27-12-14-29-16-17-30-15-13-28-11-9-22-20(25)8-6-4-5-7-19-18(2)23-21(26)24-19/h1,18-19H,4-17H2,2H3,(H,22,25)(H2,23,24,26)/t18-,19+/m0/s1
• InChIKey: CQSNBVBVAYQBHF-RBUKOAKNSA-N
• SMILES: C[C@H]1[C@H](NC(=O)N1)CCCCCC(=O)NCCOCCOCCOCCOCC#C

Desthiobiotin-PEG4-propargyl（Cat No.:I044716）is a multifunctional reagent designed for bioconjugation and affinity-based applications. It features desthiobiotin, a biotin analog that binds reversibly to streptavidin, allowing for gentle elution in purification workflows. The PEG4 spacer enhances water solubility, flexibility, and reduces nonspecific binding, while the terminal propargyl group enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) “click” chemistry. This compound is ideal for reversible labeling, pull-down assays, and controlled release applications in proteomics, diagnostics, and targeted delivery systems, offering high specificity, low background, and compatibility with a variety of biomolecular environments.