Desthiobiotin-PEG4-acid

• CAT Number: I044623
• Molecular Formula: C21H39N3O8
• Molecular Weight: 461.55
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]hexanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C21H39N3O8/c1-17-18(24-21(28)23-17)5-3-2-4-6-19(25)22-8-10-30-12-14-32-16-15-31-13-11-29-9-7-20(26)27/h17-18H,2-16H2,1H3,(H,22,25)(H,26,27)(H2,23,24,28)/t17-,18+/m0/s1
• InChIKey: ZOYWRMMBEMRBFL-ZWKOTPCHSA-N
• SMILES: C[C@H]1[C@H](NC(=O)N1)CCCCCC(=O)NCCOCCOCCOCCOCCC(=O)O

Desthiobiotin-PEG4-acid（Cat No.:I044623）is a bifunctional molecule combining desthiobiotin, a biotin analog with reversible binding to streptavidin, and a carboxylic acid functional group, connected by a tetraethylene glycol (PEG4) spacer. The PEG4 linker enhances water solubility and provides spatial flexibility, reducing steric hindrance during bioconjugation. The acid group allows covalent coupling to amines via amide bond formation. Desthiobiotin-PEG4-acid is ideal for reversible affinity purification, surface immobilization, and protein labeling applications, particularly when controlled, non-permanent interaction with streptavidin is required in biosensing, proteomics, and diagnostic assay development.