Desmosterol-d6

• CAT Number: R049351
• CAS Number: 1246298-67-8
• Molecular Formula: C27H38D6O
• Molecular Weight: 390.67
• Purity: ≥95%
• Synonyms: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-7,7,7-trideuterio-6-(trideuteriomethyl)hept-5-en-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• InChI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1/i1D3,2D3
• InChIKey: AVSXSVCZWQODGV-QSOBUISFSA-N
• SMILES: CC(CCC=C(C)C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C

Desmosterol-d6 (Cat No.: R049351) is a stable isotope-labeled analog of desmosterol, an immediate precursor of cholesterol in the Bloch pathway of sterol biosynthesis. Incorporating six deuterium atoms, it is widely used as an internal standard in liquid chromatography–mass spectrometry (LC-MS/MS) for accurate quantification of desmosterol in biological samples. Desmosterol plays key roles in lipid metabolism, membrane biology, and signaling, and its dysregulation is linked to metabolic and neurodegenerative disorders. Desmosterol-d6 is a valuable tool for biomarker discovery, sterol metabolism studies, and clinical research.

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[Content Brief]

[2]. Clark RM, et al. Desmosterol in human milk. Lipids. 1983;18(3):264-266.
[Content Brief]