Desmethylene Paroxetine Hydrochloride Salt

• CAT Number: R013657
• CAS Number: 159126-30-4
• Molecular Formula: C₁₈H₂₁ClFNO₃
• Molecular Weight: 353.82
• Purity: ≥95%
• Synonyms: 4-[[(3S,4R)-4-(4-Fluorophenyl)-3-piperidinyl]methoxy]-1,2-benzenediol Hydrochloride; (3S-trans)-4-[[4-(4-Fluorophenyl)-3-piperidinyl]methoxy]-1,2-benzenediol Hydrochloride; BRL 36610; Paroxetine catechol
• Storage: -20°C
• IUPAC Name: 4-[[(3S,4R)-4-(4-fluorophenyl)piperidin-3-yl]methoxy]benzene-1,2-diol
• InChI: InChI=1S/C18H20FNO3/c19-14-3-1-12(2-4-14)16-7-8-20-10-13(16)11-23-15-5-6-17(21)18(22)9-15/h1-6,9,13,16,20-22H,7-8,10-11H2/t13-,16-/m0/s1
• InChIKey: VJMXXTJAPJRAQL-BBRMVZONSA-N
• SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC(=C(C=C3)O)O

Desmethylene Paroxetine Hydrochloride Salt（Cat No.:R013657）is a synthetic derivative of paroxetine, a selective serotonin reuptake inhibitor (SSRI), in which the methylene bridge in the piperidine ring is absent. This structural modification alters its interaction with the serotonin transporter, making it useful in pharmacological studies to investigate structure–activity relationships (SAR) of SSRIs. The hydrochloride salt form improves water solubility and stability for laboratory use. It is typically supplied as a white to off-white solid and is primarily used in research settings focused on antidepressant development and central nervous system (CNS) pharmacology.