Desmethyl cariprazine

• CAT Number: I017502
• CAS Number: 839712-15-1
• Molecular Formula: C20H30Cl2N4O
• Molecular Weight: 413.38
• Purity: ≥95%
• Synonyms: 1-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-3-methylurea
• InChI: InChI=1S/C20H30Cl2N4O/c1-23-20(27)24-16-7-5-15(6-8-16)9-10-25-11-13-26(14-12-25)18-4-2-3-17(21)19(18)22/h2-4,15-16H,5-14H2,1H3,(H2,23,24,27)
• InChIKey: WMQLLTKSISGWHQ-UHFFFAOYSA-N
• SMILES: CNC(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl

Desmethyl cariprazine(CAT: I017502) is a pharmacologically active metabolite of the atypical antipsychotic agent Cariprazine. Like its parent compound, it exhibits high affinity for dopamine D₃ (Ki = 0.085 nM) and D₂ receptors (Ki = 0.49 nM), as well as moderate affinity for serotonin 5-HT₁A receptors (Ki = 2.6 nM). Desmethyl cariprazine contributes to the therapeutic efficacy of Cariprazine in the treatment of schizophrenia, bipolar disorder, and other neuropsychiatric conditions by modulating dopaminergic and serotonergic signaling. As a key metabolite, it is commonly used in pharmacokinetic, pharmacodynamic, and receptor-binding studies to better understand drug metabolism, receptor selectivity, and long-acting therapeutic effects.