For research use only. Not for therapeutic Use.
Desfluoro-ezetimibe（Cat No.:R053916）is a structural analog of the cholesterol absorption inhibitor ezetimibe, differing by the absence of the fluorine atom in its aromatic ring. This modification provides a valuable tool for studying structure–activity relationships and the role of halogen substitution in drug efficacy. Like ezetimibe, desfluoro-ezetimibe targets the Niemann-Pick C1-Like 1 (NPC1L1) transporter, which mediates intestinal cholesterol uptake, but with altered potency and pharmacological properties. It is widely used in metabolic and cardiovascular research to explore cholesterol metabolism, lipid-lowering mechanisms, and potential therapeutic development.
| CAS Number | 302781-98-2 |
| Synonyms | (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one |
| Molecular Formula | C24H22FNO3 |
| Purity | ≥95% |
| IUPAC Name | (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one |
| InChI | InChI=1S/C24H22FNO3/c25-18-10-6-16(7-11-18)22(28)15-14-21-23(17-8-12-20(27)13-9-17)26(24(21)29)19-4-2-1-3-5-19/h1-13,21-23,27-28H,14-15H2/t21-,22+,23-/m1/s1 |
| InChIKey | YWZUFJFIXFJKBD-XPWALMASSA-N |
| SMILES | C1=CC=C(C=C1)N2[C@@H]([C@H](C2=O)CC[C@@H](C3=CC=C(C=C3)F)O)C4=CC=C(C=C4)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
