For research use only. Not for therapeutic Use.
Deschloroclozapine dihydrochloride(CAT: I040264) is a highly potent and selective agonist for muscarinic DREADDs (Designer Receptors Exclusively Activated by Designer Drugs), functioning as an active metabolite of clozapine. It binds with high affinity to hM3Dq and hM4Di receptor subtypes, exhibiting KI values of 6.3 nM and 4.2 nM, respectively. Deschloroclozapine enables precise chemogenetic modulation of neuronal activity in vivo and in vitro, making it a valuable tool for neuroscience and behavioral studies. Additionally, its radiolabeled form, [¹¹C]-Deschloroclozapine, is used as a promising PET tracer for imaging DREADD expression. For research use only; not for diagnostic or therapeutic applications.
| Synonyms | 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine;dihydrochloride |
| Molecular Formula | C18H22Cl2N4 |
| Purity | ≥95% |
| IUPAC Name | 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine;dihydrochloride |
| InChI | InChI=1S/C18H20N4.2ClH/c1-21-10-12-22(13-11-21)18-14-6-2-3-7-15(14)19-16-8-4-5-9-17(16)20-18;;/h2-9,19H,10-13H2,1H3;2*1H |
| InChIKey | ZMDCCOPUWCVMFM-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=NC3=CC=CC=C3NC4=CC=CC=C42.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
