• CAT Number: I006358
  • CAS Number: 251945-92-3
  • Molecular Formula: C18H20N4O
  • Molecular Weight: 308.385
  • Purity: ≥95%
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Derenofylline (CAT: I006358), also known as SLV320, is a potent and selective adenosine A(1) antagonist (Ki=1 nM). It exhibits over 200-fold selectivity for the A(1) receptor compared to other adenosine receptor subtypes. In preclinical studies, SLV320 has shown promise in reducing albuminuria without affecting the glomerular filtration rate (GFR). It has also demonstrated protective effects in preventing the rise of plasma markers associated with nephrectomy. Additionally, SLV320 has shown the ability to attenuate cardiac fibrosis and albuminuria without impacting blood pressure in animal models.

Catalog Number I006358
CAS Number 251945-92-3
Molecular Formula


Purity 95%
Target Adenosine Receptor
Solubility Soluble in DMSO, not in water
Storage Store at RT
IUPAC Name 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol
InChI InChI=1S/C18H20N4O/c23-14-8-6-13(7-9-14)20-18-15-10-11-19-17(15)21-16(22-18)12-4-2-1-3-5-12/h1-5,10-11,13-14,23H,6-9H2,(H2,19,20,21,22)

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1:Pang PS, Mehra M, Maggioni AP, Filippatos G, Middlebrooks J, Turlapaty P, Kazei D, Gheorghiade M; RENO-DEFEND Investigators. Rationale, design, and results from RENO-DEFEND 1: a randomized, dose-finding study of the selective A1 adenosine antagonist SLV320 in patients hospitalized with acute heart failure. Am Heart J. 2011 Jun;161(6):1012-23.e3. doi: 10.1016/j.ahj.2011.03.004. PubMed PMID: 21641345. <br />
2: Mitrovic V, Seferovic P, Dodic S, Krotin M, Neskovic A, Dickstein K, de Voogd H, B&#246;cker C, Ziegler D, Godes M, Nakov R, Essers H, Verboom C, Hocher B. Cardio-renal effects of the A1 adenosine receptor antagonist SLV320 in patients with heart failure. Circ Heart Fail. 2009 Nov;2(6):523-31. doi: 10.1161/CIRCHEARTFAILURE.108.798389. Epub 2009 Sep 24. PubMed PMID: 19919976.

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