DEPTOR-IN-1

• CAT Number: I045335
• CAS Number: 2615911-12-9
• Molecular Formula: C24H16Cl2FNO4
• Molecular Weight: 472.29
• Purity: ≥95%
• Synonyms: 2-(3,4-dichlorophenyl)-9-[(3-fluorophenyl)methyl]-3-hydroxy-8,10-dihydropyrano[2,3-f][1,3]benzoxazin-4-one
• InChI: InChI=1S/C24H16Cl2FNO4/c25-18-6-4-14(9-19(18)26)23-22(30)21(29)16-5-7-20-17(24(16)32-23)11-28(12-31-20)10-13-2-1-3-15(27)8-13/h1-9,30H,10-12H2
• InChIKey: YHKREPOFPNSZAL-UHFFFAOYSA-N
• SMILES: C1C2=C(C=CC3=C2OC(=C(C3=O)O)C4=CC(=C(C=C4)Cl)Cl)OCN1CC5=CC(=CC=C5)F

DEPTOR‑IN‑1 (Cat No.: I045335) is a putative small‑molecule inhibitor of DEPTOR (DEP domain‑containing mTOR‑interacting protein), with a reported binding affinity (Kd) of approximately 9.3 µM. In vitro studies show modest antiproliferative activity in cancer cell lines, with IC₅₀ values ranging from ~1.1 µM in RPMI‑8226 to ~10 µM in HL‑60, MCF‑7, and others after 72 h exposure. DEPTOR‑IN‑1 is used as a molecular probe to study mTOR pathway regulation via DEPTOR modulation in cancer and related translational research.

Reference

[1]. Hou Y, et al. Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment. J Med Chem. 2021 Oct 28;64(20):14942-14954.
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