Dehydroaripiprazole

• CAT Number: R017270
• CAS Number: 129722-25-4
• Molecular Formula: C23H25Cl2N3O2
• Molecular Weight: 446.37
• Purity: ≥95%
• Synonyms: 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-1H-quinolin-2-one
• InChI: InChI=1S/C23H25Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-9,16H,1-2,10-15H2,(H,26,29)
• InChIKey: CDONPRYEWWPREK-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C(C(=CC=C4)Cl)Cl

Dehydroaripiprazole(CAT: R017270) is the primary active metabolite of the atypical antipsychotic aripiprazole. It contributes significantly to the parent drug’s therapeutic profile through partial agonism at dopamine D₂ and serotonin 5-HT₁A receptors, alongside antagonism at 5-HT₂A receptors. This metabolite exhibits a long half-life, supporting sustained pharmacological effects in neuropsychiatric conditions. Dehydroaripiprazole is frequently studied in pharmacokinetic and pharmacodynamic research to better understand aripiprazole’s efficacy, metabolism, and patient variability in response. It serves as a valuable reference compound in the fields of psychiatry, neuroscience, and drug development, providing insight into antipsychotic mechanisms and therapeutic optimization strategies.