DDR1-IN-4

• CAT Number: I015374
• CAS Number: 2125676-13-1
• Molecular Formula: C23H20BrF3N6O3
• Molecular Weight: 565.34
• Purity: ≥95%
• Synonyms: 2-[4-bromo-2-oxo-1′-(1H-pyrazolo[4,3-b]pyridine-5-carbonyl)spiro[indole-3,4′-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide
• IUPAC Name: 2-[4-bromo-2-oxo-1'-(1H-pyrazolo[4,3-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide
• InChI: InChI=1S/C23H20BrF3N6O3/c24-13-2-1-3-17-19(13)22(21(36)33(17)11-18(34)28-12-23(25,26)27)6-8-32(9-7-22)20(35)15-5-4-14-16(30-15)10-29-31-14/h1-5,10H,6-9,11-12H2,(H,28,34)(H,29,31)
• InChIKey: UXEXYURPAPXPSR-UHFFFAOYSA-N
• SMILES: C1CN(CCC12C3=C(C=CC=C3Br)N(C2=O)CC(=O)NCC(F)(F)F)C(=O)C4=NC5=C(C=C4)NN=C5

DDR1-IN-4（Cat No.:I015374）is a selective small-molecule inhibitor targeting Discoidin Domain Receptor 1 (DDR1), a receptor tyrosine kinase activated by collagen. Overactivation of DDR1 is implicated in cancer progression, fibrosis, and inflammatory diseases. By blocking DDR1 signaling, DDR1-IN-4 disrupts tumor cell proliferation, epithelial–mesenchymal transition, and pathological extracellular matrix remodeling. Researchers utilize DDR1-IN-4 to investigate DDR1-driven pathways, evaluate anti-fibrotic strategies, and assess therapeutic potential in oncology and chronic inflammatory conditions. Its potency and selectivity make it a valuable tool for preclinical drug discovery and mechanistic studies.