DDO-5936

• CAT Number: I025648
• CAS Number: 2355377-13-6
• Molecular Formula: C25H29N5O4S
• Molecular Weight: 495.59
• Purity: ≥95%
• Synonyms: 2-[4-[(2-pyrrolidin-1-ylpyrimidin-4-yl)amino]-N-(2,4,6-trimethylphenyl)sulfonylanilino]acetic acid
• InChI: InChI=1S/C25H29N5O4S/c1-17-14-18(2)24(19(3)15-17)35(33,34)30(16-23(31)32)21-8-6-20(7-9-21)27-22-10-11-26-25(28-22)29-12-4-5-13-29/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H,31,32)(H,26,27,28)
• InChIKey: IIPYRKNROAWEPK-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CC(=O)O)C2=CC=C(C=C2)NC3=NC(=NC=C3)N4CCCC4)C

DDO-5936（Cat No.:I025648）is a selective small-molecule inhibitor that disrupts the interaction between heat shock protein 90 (HSP90) and co-chaperone Cdc37, a critical complex involved in the stabilization and activation of various protein kinases. By selectively blocking this interaction, DDO-5936 impairs the maturation of oncogenic kinases without broadly inhibiting HSP90’s ATPase function, reducing toxicity compared to traditional HSP90 inhibitors. It has shown anticancer activity in preclinical models, particularly in tumors driven by Cdc37-dependent kinases. DDO-5936 is a valuable tool for studying chaperone-mediated kinase regulation and developing targeted cancer therapies.