DD-03-156

• CAT Number: I044099
• CAS Number: 2769753-69-5
• Molecular Formula: C53H62F3N9O8S3
• Molecular Weight: 1106.31
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-[3-[2-[2-[[4-[2-tert-butyl-4-[3-[(2,6-difluorophenyl)sulfonylamino]-2-fluorophenyl]-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]ethoxy]ethoxy]propanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C53H62F3N9O8S3/c1-30(32-15-17-33(18-16-32)44-31(2)59-29-74-44)60-48(68)40-27-34(66)28-65(40)49(69)47(52(3,4)5)62-41(67)20-23-72-25-26-73-24-22-58-51-57-21-19-39(61-51)45-43(63-50(75-45)53(6,7)8)35-11-9-14-38(42(35)56)64-76(70,71)46-36(54)12-10-13-37(46)55/h9-19,21,29-30,34,40,47,64,66H,20,22-28H2,1-8H3,(H,60,68)(H,62,67)(H,57,58,61)/t30-,34+,40-,47+/m0/s1
• InChIKey: BMLDGVCSNFURAJ-QUQZIOAQSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCOCCOCCNC4=NC=CC(=N4)C5=C(N=C(S5)C(C)(C)C)C6=C(C(=CC=C6)NS(=O)(=O)C7=C(C=CC=C7F)F)F)O

DD-03-156（Cat No.:I044099）is a potent small-molecule activator of the mitochondrial protease ClpP (caseinolytic mitochondrial matrix peptidase proteolytic subunit). By hyperactivating ClpP, DD-03-156 disrupts mitochondrial protein homeostasis, leading to the degradation of key respiratory chain proteins and induction of mitochondrial stress. This compound is particularly valuable in cancer research, where mitochondrial dysfunction can selectively impair tumor cell viability, especially in oxidative phosphorylation-dependent cancers. DD-03-156 is used to investigate mitochondrial quality control mechanisms, ClpP biology, and to explore therapeutic strategies targeting mitochondrial vulnerabilities in cancer and other metabolic disorders.