dCBP-1

• CAT Number: I044565
• CAS Number: 2484739-25-3
• Molecular Formula: C51H63F2N11O10
• Molecular Weight: 1028.11
• Purity: ≥95%
• Synonyms: 3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[1-[3-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoyl]piperidin-4-yl]-N-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
• InChI: InChI=1S/C51H63F2N11O10/c1-54-51(70)61-17-11-41-40(31-61)47(62-14-3-4-32-26-37(33-29-56-59(2)30-33)38(46(52)53)28-43(32)62)58-64(41)35-9-15-60(16-10-35)45(66)12-18-71-20-22-73-24-25-74-23-21-72-19-13-55-34-5-6-36-39(27-34)50(69)63(49(36)68)42-7-8-44(65)57-48(42)67/h5-6,26-30,35,42,46,55H,3-4,7-25,31H2,1-2H3,(H,54,70)(H,57,65,67)
• InChIKey: ILVRLRGBSSFKIE-UHFFFAOYSA-N
• SMILES: CNC(=O)N1CCC2=C(C1)C(=NN2C3CCN(CC3)C(=O)CCOCCOCCOCCOCCNC4=CC5=C(C=C4)C(=O)N(C5=O)C6CCC(=O)NC6=O)N7CCCC8=CC(=C(C=C87)C(F)F)C9=CN(N=C9)C

dCBP-1（Cat No.:I044565）is a potent and selective inhibitor of the CREB-binding protein (CBP) and its paralog p300, both of which are histone acetyltransferases (HATs) involved in chromatin remodeling and transcriptional regulation. dCBP-1 disrupts the interaction between CBP/p300 and transcriptional activators, thereby modulating gene expression linked to cell growth, differentiation, and oncogenesis. It exhibits high selectivity and efficacy in preclinical models, making it a valuable chemical probe for studying epigenetic mechanisms. dCBP-1 holds therapeutic potential in cancer and inflammatory diseases where CBP/p300-mediated transcriptional dysregulation plays a key role.