DBM-MMAF

• CAT Number: I015226
• CAS Number: 1810001-93-4
• Molecular Formula: C49H74Br2N6O11
• Molecular Weight: 1082.95
• Purity: ≥95%
• Synonyms: (2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[6-(3,4-dibromo-2,5-dioxopyrrol-1-yl)hexanoyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl]amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C49H74Br2N6O11/c1-12-30(6)42(35(67-10)27-37(59)56-25-19-22-34(56)43(68-11)31(7)44(60)52-33(49(65)66)26-32-20-15-13-16-21-32)55(9)48(64)40(28(2)3)53-45(61)41(29(4)5)54(8)36(58)23-17-14-18-24-57-46(62)38(50)39(51)47(57)63/h13,15-16,20-21,28-31,33-35,40-43H,12,14,17-19,22-27H2,1-11H3,(H,52,60)(H,53,61)(H,65,66)/t30-,31+,33-,34-,35+,40-,41-,42-,43+/m0/s1
• InChIKey: GZSVYZUXQREYGL-ZHOZFWKKSA-N
• SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN3C(=O)C(=C(C3=O)Br)Br

DBM-MMAF（Cat No.:I015226）is a potent antibody–drug conjugate (ADC) payload designed for targeted cancer therapy research. It consists of monomethyl auristatin F (MMAF), a synthetic antimitotic agent that inhibits tubulin polymerization and disrupts microtubule dynamics, leading to cell cycle arrest and apoptosis. Conjugated through a dibenzomaleimide (DBM) linker, this construct enables site-specific and stable attachment to antibodies or biomolecules. Compared to MMAE, MMAF exhibits reduced membrane permeability, providing improved tumor selectivity and safety. DBM-MMAF is widely used in ADC design, oncology, and chemical biology research.