DBIBB

• CAT Number: R029700
• CAS Number: 1569309-92-7
• Molecular Formula: C23H20N2O6S
• Molecular Weight: 452.48
• Purity: ≥95%
• Synonyms: 2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid
• InChI: InChI=1S/C23H20N2O6S/c26-21-17-10-5-7-15-8-6-11-18(20(15)17)22(27)25(21)14-4-3-13-24-32(30,31)19-12-2-1-9-16(19)23(28)29/h1-2,5-12,24H,3-4,13-14H2,(H,28,29)
• InChIKey: POLJNARIJSROOS-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)O)S(=O)(=O)NCCCCN2C(=O)C3=CC=CC4=C3C(=CC=C4)C2=O

DBIBB（Cat No.:R029700）is a potent, selective non-lipid agonist of the lysophosphatidic acid receptor 2 (LPA₂), exhibiting an EC₅₀ of 100 nM. It does not activate other LPA receptor subtypes, ensuring targeted action . DBIBB mitigates gastrointestinal and hematopoietic acute radiation syndromes by enhancing intestinal crypt survival, promoting enterocyte proliferation, and reducing apoptosis . It also enhances DNA repair and increases survival of irradiated hematopoietic progenitor cells . Notably, DBIBB remains effective even when administered up to 72 hours post-irradiation, highlighting its potential as a radiomitigator .