For research use only. Not for therapeutic Use.
dBET23 (Cat No.: I025583) is a proteolysis-targeting chimera (PROTAC) designed to induce selective degradation of BRD4, a member of the BET (bromodomain and extra-terminal) family of epigenetic reader proteins. It consists of a BRD4-binding ligand linked to a cereblon (CRBN) E3 ubiquitin ligase ligand, promoting ubiquitination and proteasomal degradation of BRD4. By removing BRD4, dBET23 disrupts transcription of oncogenes such as MYC, leading to antiproliferative effects in cancer cells. It is widely used in chemical biology and oncology research to study targeted protein degradation strategies.
| CAS Number | 1957234-83-1 |
| Synonyms | methyl 2-[(9S)-7-(4-chlorophenyl)-4-[8-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]octylcarbamoyl]-5,13-dimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate |
| Molecular Formula | C43H45ClN8O9S |
| Purity | ≥95% |
| InChI | InChI=1S/C43H45ClN8O9S/c1-23-34-36(25-13-15-26(44)16-14-25)47-28(21-33(55)60-3)38-50-49-24(2)51(38)43(34)62-37(23)40(57)46-20-9-7-5-4-6-8-19-45-32(54)22-61-30-12-10-11-27-35(30)42(59)52(41(27)58)29-17-18-31(53)48-39(29)56/h10-16,28-29H,4-9,17-22H2,1-3H3,(H,45,54)(H,46,57)(H,48,53,56)/t28-,29?/m0/s1 |
| InChIKey | ZIHIUFZFPMILIG-XLTVJXRZSA-N |
| SMILES | CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC)C4=CC=C(C=C4)Cl)C(=O)NCCCCCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O |
| Reference | [1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018;14(7):706-714. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
