DBCO-PEG4-triethoxysilane

• CAT Number: I016047
• CAS Number: 2353410-02-1
• Molecular Formula: C39H57N3O10Si
• Molecular Weight: 755.97
• Purity: ≥95%
• Synonyms: 4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxo-N-[2-[2-[2-[2-[3-oxo-3-(3-triethoxysilylpropylamino)propoxy]ethoxy]ethoxy]ethoxy]ethyl]butanamide
• InChI: InChI=1S/C39H57N3O10Si/c1-4-50-53(51-5-2,52-6-3)31-11-21-40-38(44)20-23-46-25-27-48-29-30-49-28-26-47-24-22-41-37(43)18-19-39(45)42-32-35-14-8-7-12-33(35)16-17-34-13-9-10-15-36(34)42/h7-10,12-15H,4-6,11,18-32H2,1-3H3,(H,40,44)(H,41,43)
• InChIKey: BVPATRYMIHMPFW-UHFFFAOYSA-N
• SMILES: CCO[Si](CCCNC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31)(OCC)OCC

DBCO-PEG4-triethoxysilane（Cat No.:I016047）is a heterobifunctional linker that combines a dibenzocyclooctyne (DBCO) group with a triethoxysilane functionality, separated by a PEG4 spacer. The DBCO moiety enables copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides, providing fast and selective bioorthogonal conjugation under physiological conditions. The triethoxysilane group reacts with hydroxylated surfaces such as glass, silica, or metal oxides, enabling stable covalent attachment for surface modification. The PEG4 chain enhances solubility, imparts flexibility, and minimizes steric hindrance. This reagent is ideal for biomaterials engineering, biosensor development, and surface functionalization in chemical biology.