DBCO-PEG4-C2-acid

• CAT Number: I016368
• CAS Number: 1537170-85-6
• Molecular Formula: C30H36N2O8
• Molecular Weight: 552.62
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C30H36N2O8/c33-28(31-14-16-38-18-20-40-22-21-39-19-17-37-15-13-30(35)36)11-12-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32/h1-8H,11-23H2,(H,31,33)(H,35,36)
• InChIKey: LKSAMQQFMTVPKD-UHFFFAOYSA-N
• SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCOCCOCCOCCOCCC(=O)O

DBCO-PEG4-C2-acid(CAT: I016368) is a versatile azide-reactive linker that combines a dibenzocyclooctyne (DBCO) group with a short PEG4 spacer and a terminal carboxylic acid. The DBCO moiety enables copper-free strain-promoted alkyne–azide cycloaddition (SPAAC), allowing rapid and selective conjugation to azide-containing biomolecules under mild, biocompatible conditions. The PEG4 spacer enhances solubility, minimizes steric hindrance, and improves molecular flexibility, while the terminal carboxylic acid provides a handle for further derivatization or coupling to amine-containing molecules through standard carbodiimide chemistry. This reagent is widely used in bioconjugation, drug delivery, and click chemistry applications where copper-free, efficient, and stable linkages are essential.