DBCO-PEG24-acid

• CAT Number: I042575
• CAS Number: 2765066-36-0
• Molecular Formula: C70H116N2O28
• Molecular Weight: 1433.67
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C70H116N2O28/c73-68(11-12-69(74)72-63-66-7-2-1-5-64(66)9-10-65-6-3-4-8-67(65)72)71-14-16-78-18-20-80-22-24-82-26-28-84-30-32-86-34-36-88-38-40-90-42-44-92-46-48-94-50-52-96-54-56-98-58-60-100-62-61-99-59-57-97-55-53-95-51-49-93-47-45-91-43-41-89-39-37-87-35-33-85-31-29-83-27-25-81-23-21-79-19-17-77-15-13-70(75)76/h1-8H,11-63H2,(H,71,73)(H,75,76)
• InChIKey: UQDUEOCZBDBAER-UHFFFAOYSA-N
• SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

DBCO-PEG24-acid (Cat No.: I042575) is a bifunctional, long-chain polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group and a terminal carboxylic acid. The DBCO moiety enables copper-free click chemistry with azide-functionalized molecules via strain-promoted alkyne-azide cycloaddition (SPAAC), while the carboxylic acid allows further conjugation through amide bond formation. The PEG24 spacer enhances water solubility, flexibility, and reduces steric hindrance. DBCO-PEG24-acid is widely used in bioconjugation, drug delivery systems, and surface modification for developing targeted therapeutics, imaging probes, and biofunctionalized materials.

Reference

[1]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.
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