DBCO-PEG2-DBCO

• CAT Number: I042573
• CAS Number: 2639395-48-3
• Molecular Formula: C44H42N4O6
• Molecular Weight: 722.83
• Purity: ≥95%
• Synonyms: 4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-N-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethyl]-4-oxobutanamide
• InChI: InChI=1S/C44H42N4O6/c49-41(21-23-43(51)47-31-37-13-3-1-9-33(37)17-19-35-11-5-7-15-39(35)47)45-25-27-53-29-30-54-28-26-46-42(50)22-24-44(52)48-32-38-14-4-2-10-34(38)18-20-36-12-6-8-16-40(36)48/h1-16H,21-32H2,(H,45,49)(H,46,50)
• InChIKey: GPRBYNSGOSAHPU-UHFFFAOYSA-N
• SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCOCCOCCNC(=O)CCC(=O)N4CC5=CC=CC=C5C#CC6=CC=CC=C64

DBCO-PEG2-DBCO (Cat No.: I042573) is a bifunctional crosslinker featuring two dibenzocyclooctyne (DBCO) groups connected by a short polyethylene glycol (PEG2) spacer. It enables efficient copper-free click chemistry (SPAAC) with azide-containing molecules, facilitating bioconjugation under mild, bioorthogonal conditions. The PEG2 linker provides flexibility and water solubility, enhancing reactivity and minimizing steric hindrance. DBCO-PEG2-DBCO is widely used in biomaterials, drug delivery systems, and molecular imaging to create stable, covalently linked macromolecular assemblies, nanoparticles, and surface modifications in a highly specific and biocompatible manner.

Reference

[1]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.
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