DBCO-NH-Boc

• CAT Number: I016053
• CAS Number: 1539290-74-8
• Molecular Formula: C23H24N2O3
• Molecular Weight: 376.45
• Purity: ≥95%
• Synonyms: tert-butyl N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]carbamate
• InChI: InChI=1S/C23H24N2O3/c1-23(2,3)28-22(27)24-15-14-21(26)25-16-19-10-5-4-8-17(19)12-13-18-9-6-7-11-20(18)25/h4-11H,14-16H2,1-3H3,(H,24,27)
• InChIKey: REYNVEBGFQGBTG-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31

DBCO-NH-Boc（Cat No.:I016053）is a dibenzocyclooctyne (DBCO) derivative functionalized with a tert-butoxycarbonyl (Boc)-protected amine. The DBCO group enables copper-free strain-promoted azide–alkyne cycloaddition (SPAAC), offering fast, selective, and biocompatible conjugation with azides. The Boc-protected amine serves as a latent functional handle, which can be deprotected under mild acidic conditions to yield a free primary amine for further coupling with carboxylic acids, activated esters, or isocyanates. This dual functionality provides orthogonal reactivity, making DBCO-NH-Boc a versatile tool in chemical biology, drug conjugation, biomaterials engineering, and bioorthogonal chemistry applications.