DB772

• CAT Number: I025575
• CAS Number: 1451058-50-6
• Molecular Formula: C20H18Cl2N4O
• Molecular Weight: 401.29
• Purity: ≥95%
• Synonyms: 2-[5-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]furan-2-yl]-1H-benzimidazole;dihydrochloride
• InChI: InChI=1S/C20H16N4O.2ClH/c1-2-4-16-15(3-1)23-20(24-16)18-10-9-17(25-18)13-5-7-14(8-6-13)19-21-11-12-22-19;;/h1-10H,11-12H2,(H,21,22)(H,23,24);2*1H
• InChIKey: HXHWZHFJICNTMP-UHFFFAOYSA-N
• SMILES: C1CN=C(N1)C2=CC=C(C=C2)C3=CC=C(O3)C4=NC5=CC=CC=C5N4.Cl.Cl

DB772 (Cat No.: I025575) is an aromatic diamidine compound with potent antiparasitic and antiviral activity. It has been studied as an inhibitor of Trypanosoma and Leishmania species, as well as several DNA and RNA viruses. DB772 acts by binding to the minor groove of DNA, interfering with replication and transcription processes. In research, it is widely used to investigate host–pathogen interactions, nucleic acid binding mechanisms, and potential therapeutic strategies against protozoal infections. DB772 serves as a valuable chemical probe in parasitology and virology studies.

Reference

[1]. James B Stanton, et al. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173.
[Content Brief]

[2]. Benjamin W Newcomer, et al. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96(2):127-9.
[Content Brief]

[3]. Kelcey D Dinkel, et al. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5467-82.
[Content Brief]