DB2115 tertahydrochloride

• CAT Number: I044365
• CAS Number: 1366126-19-3
• Molecular Formula: C32H34Cl4N8O2
• Molecular Weight: 704.48
• Purity: ≥95%
• Synonyms: 2-[4-[4-[4-(6-carbamimidoyl-1H-benzimidazol-2-yl)phenoxy]butoxy]phenyl]-3H-benzimidazole-5-carboximidamide;tetrahydrochloride
• InChI: InChI=1S/C32H30N8O2.4ClH/c33-29(34)21-7-13-25-27(17-21)39-31(37-25)19-3-9-23(10-4-19)41-15-1-2-16-42-24-11-5-20(6-12-24)32-38-26-14-8-22(30(35)36)18-28(26)40-32;;;;/h3-14,17-18H,1-2,15-16H2,(H3,33,34)(H3,35,36)(H,37,39)(H,38,40);4*1H
• InChIKey: ADRCMNUIKDHGQW-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=N)N)OCCCCOC4=CC=C(C=C4)C5=NC6=C(N5)C=C(C=C6)C(=N)N.Cl.Cl.Cl.Cl

DB2115 tetrahydrochloride（Cat No.:I044365）is a small-molecule compound developed as a selective antagonist of the α9α10 nicotinic acetylcholine receptor (nAChR), a receptor subtype primarily expressed in cochlear hair cells and certain immune cells. By inhibiting α9α10 nAChRs, DB2115 tetrahydrochloride has demonstrated potential in treating auditory disorders such as noise-induced hearing loss and tinnitus. It may also modulate inflammatory responses, given the role of α9α10 nAChRs in immune signaling. The tetrahydrochloride salt form improves the compound’s solubility and stability, making it suitable for pharmacological studies in auditory neuroscience and inflammation research.