For research use only. Not for therapeutic Use.
DB-3-291（Cat No.:I044100）is a potent and selective small-molecule activator of the mitochondrial protease ClpP, designed to disrupt mitochondrial protein homeostasis by promoting uncontrolled degradation of essential mitochondrial proteins. This leads to mitochondrial dysfunction, impaired oxidative phosphorylation, and ultimately cancer cell death, particularly in tumors that rely heavily on mitochondrial respiration. DB-3-291 is widely used in oncology research to explore mitochondrial stress responses, ClpP activation mechanisms, and novel therapeutic strategies targeting mitochondrial proteostasis. It serves as a valuable tool for identifying metabolic vulnerabilities in cancer and advancing mitochondria-directed anticancer therapies.
| CAS Number | 2769753-64-0 |
| Synonyms | N-(2-chloro-6-methylphenyl)-2-[[6-[4-[2-[4-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]butylamino]-2-oxoethyl]piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
| Molecular Formula | C41H44ClN11O8S |
| Purity | ≥95% |
| IUPAC Name | N-(2-chloro-6-methylphenyl)-2-[[6-[4-[2-[4-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]butylamino]-2-oxoethyl]piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
| InChI | InChI=1S/C41H44ClN11O8S/c1-23-7-5-9-26(42)36(23)50-38(58)29-20-45-41(62-29)48-30-19-31(47-24(2)46-30)52-17-15-51(16-18-52)21-33(55)43-13-3-4-14-44-34(56)22-61-28-10-6-8-25-35(28)40(60)53(39(25)59)27-11-12-32(54)49-37(27)57/h5-10,19-20,27H,3-4,11-18,21-22H2,1-2H3,(H,43,55)(H,44,56)(H,50,58)(H,49,54,57)(H,45,46,47,48) |
| InChIKey | NYBFKYHLTFWMOL-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CC(=O)NCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
