For research use only. Not for therapeutic Use.
DB-0646（Cat No.:I044102）is a selective small-molecule activator of the mitochondrial protease ClpP, designed to disrupt mitochondrial protein homeostasis by enhancing ClpP’s proteolytic activity. This activation leads to the degradation of key mitochondrial respiratory proteins, resulting in mitochondrial stress, impaired oxidative phosphorylation, and selective cancer cell death. DB-0646 is especially useful in studying tumors that depend on mitochondrial metabolism and is a promising agent in the development of mitochondria-targeted cancer therapies. It serves as a valuable research tool for understanding ClpP biology, metabolic reprogramming, and stress-induced apoptotic pathways in oncology.
| Synonyms | N-[3-[7-[[6-[4-[[1-[5-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxypentyl]triazol-4-yl]methyl]piperazin-1-yl]pyridin-3-yl]amino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide |
| Molecular Formula | C52H51F3N14O7 |
| Purity | ≥95% |
| IUPAC Name | N-[3-[7-[[6-[4-[[1-[5-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxypentyl]triazol-4-yl]methyl]piperazin-1-yl]pyridin-3-yl]amino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide |
| InChI | InChI=1S/C52H51F3N14O7/c1-31-12-13-35(58-46(71)32-8-6-9-34(24-32)52(53,54)55)25-40(31)68-28-33-26-57-50(61-45(33)64(2)51(68)75)59-36-14-16-42(56-27-36)66-21-19-65(20-22-66)29-37-30-67(63-62-37)18-4-3-5-23-76-41-11-7-10-38-44(41)49(74)69(48(38)73)39-15-17-43(70)60-47(39)72/h6-14,16,24-27,30,39H,3-5,15,17-23,28-29H2,1-2H3,(H,58,71)(H,57,59,61)(H,60,70,72) |
| InChIKey | BDNROHBTZXVJDB-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CN=C(C=C5)N6CCN(CC6)CC7=CN(N=N7)CCCCCOC8=CC=CC9=C8C(=O)N(C9=O)C1CCC(=O)NC1=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
