Dazucorilant

• CAT Number: I025566
• CAS Number: 1496508-34-9
• Molecular Formula: C29H22F4N4O3S
• Molecular Weight: 582.57
• Purity: ≥95%
• Synonyms: [(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
• InChI: InChI=1S/C29H22F4N4O3S/c30-22-6-8-23(9-7-22)37-26-15-21-12-14-36(41(39,40)24-10-4-20(5-11-24)29(31,32)33)18-28(21,16-19(26)17-35-37)27(38)25-3-1-2-13-34-25/h1-11,13,15,17H,12,14,16,18H2/t28-/m0/s1
• InChIKey: VXOBXKQLNWYQPQ-NDEPHWFRSA-N
• SMILES: C1CN(CC2(C1=CC3=C(C2)C=NN3C4=CC=C(C=C4)F)C(=O)C5=CC=CC=N5)S(=O)(=O)C6=CC=C(C=C6)C(F)(F)F

Dazucorilant (Cat No.: I025566)is an investigational selective glucocorticoid receptor antagonist being developed for the treatment of cortisol-driven diseases, such as Cushing’s syndrome and certain cancers. By blocking glucocorticoid receptor activation without affecting mineralocorticoid receptors, dazucorilant aims to reduce the harmful effects of excess cortisol, including metabolic dysfunction and immune suppression. Its selectivity offers an improved safety profile over earlier antagonists like mifepristone. Dazucorilant is currently in clinical trials and holds promise as a targeted therapy for endocrine and stress-related disorders.

Reference

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[3]. Canet G, et al. Central Role of Glucocorticoid Receptors in Alzheimer’s Disease and Depression. Front Neurosci. 2018;12:739. Published 2018 Oct 16.
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