For research use only. Not for therapeutic Use.
Dasatinib metabolite M6 (Cat No.: R010152) is a primary oxidative metabolite of dasatinib, a multi-targeted tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Formed mainly via cytochrome P450-mediated metabolism, M6 retains structural similarity to dasatinib but generally exhibits reduced kinase inhibitory activity. Studying M6 helps in understanding dasatinib’s pharmacokinetics, biotransformation, and elimination pathways. It is used in drug metabolism and pharmacokinetic (DMPK) research to assess metabolite safety, bioactivity, and contributions to the overall therapeutic and toxicological profile.
| CAS Number | 910297-53-9 |
| Synonyms | 2-[4-[6-[[5-[(2-chloro-6-methylphenyl)carbamoyl]-1,3-thiazol-2-yl]amino]-2-methylpyrimidin-4-yl]piperazin-1-yl]acetic acid |
| Molecular Formula | C22H24ClN7O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C22H24ClN7O3S/c1-13-4-3-5-15(23)20(13)28-21(33)16-11-24-22(34-16)27-17-10-18(26-14(2)25-17)30-8-6-29(7-9-30)12-19(31)32/h3-5,10-11H,6-9,12H2,1-2H3,(H,28,33)(H,31,32)(H,24,25,26,27) |
| InChIKey | VMCDXJFWSYUNPO-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CC(=O)O |
| Reference | [1]. Lisa J Christopher, et al. Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys. Drug Metab Dispos. 2008 Jul;36(7):1341-56. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
