Dapansutrile(CAT: I019323), also known as MCC950, is a potent and selective inhibitor of the NLRP3 inflammasome, a protein complex involved in the activation of inflammatory responses. By inhibiting the NLRP3 inflammasome, dapansutrile reduces the production of pro-inflammatory cytokines, such as IL-1β and IL-18, thereby exerting anti-inflammatory effects. Additionally, dapansutrile has been shown to possess analgesic activity, potentially providing relief from pain associated with inflammatory conditions. Its oral bioavailability makes dapansutrile a promising candidate for the treatment of inflammatory diseases.
| Catalog Number | I019323 |
| CAS Number | 54863-37-5 |
| Molecular Formula | C₄H₇NO₂S |
| Purity | ≥95% |
| Reference | [1]. Toldo S, et al. The NLRP3 Inflammasome Inhibitor, Dapansutrile, Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222. |
