Danicopan

• CAT Number: I017972
• CAS Number: 1903768-17-1
• Molecular Formula: C26H23BrFN7O3
• Molecular Weight: 580.41
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[2-[3-acetyl-5-(2-methylpyrimidin-5-yl)indazol-1-yl]acetyl]-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide
• IUPAC Name: (2S,4R)-1-[2-[3-acetyl-5-(2-methylpyrimidin-5-yl)indazol-1-yl]acetyl]-N-(6-bromo-2-pyridinyl)-4-fluoropyrrolidine-2-carboxamide
• InChI: InChI=1S/C26H23BrFN7O3/c1-14(36)25-19-8-16(17-10-29-15(2)30-11-17)6-7-20(19)35(33-25)13-24(37)34-12-18(28)9-21(34)26(38)32-23-5-3-4-22(27)31-23/h3-8,10-11,18,21H,9,12-13H2,1-2H3,(H,31,32,38)/t18-,21+/m1/s1
• InChIKey: PIBARDGJJAGJAJ-NQIIRXRSSA-N
• SMILES: CC1=NC=C(C=N1)C2=CC3=C(C=C2)N(N=C3C(=O)C)CC(=O)N4C[C@@H](C[C@H]4C(=O)NC5=NC(=CC=C5)Br)F

Danicopan (Cat No.:I017972) is a first-in-class, orally bioavailable small-molecule inhibitor of complement factor D, a serine protease essential for activation of the alternative complement pathway. By selectively blocking factor D, danicopan prevents overactivation of complement-mediated immune responses that drive rare hematologic and renal disorders. It has shown clinical benefit in paroxysmal nocturnal hemoglobinuria (PNH) by reducing hemolysis and improving hemoglobin levels, particularly in patients receiving C5 inhibitors. Danicopan is a valuable research compound for studying complement biology and therapeutic strategies in immune-mediated diseases.