For research use only. Not for therapeutic Use.
DMA-IN-1(CAT: I040353) is a small-molecule inhibitor of DNA adenine methyltransferase (DAM), an essential bacterial enzyme involved in DNA replication, repair, and gene expression regulation. With an IC₅₀ of 48 μM, DMA-IN-1 effectively disrupts methylation of adenine residues in bacterial DNA, impairing key cellular processes. It demonstrates antibacterial activity against Caulobacter crescentus, exhibiting a minimum inhibitory concentration (MIC) of 35 μM. DMA-IN-1 is a valuable research tool for studying epigenetic regulation in prokaryotes and holds promise for developing novel antimicrobial agents targeting DAM-mediated epigenetic mechanisms, particularly in the context of antibiotic resistance and bacterial pathogenicity.
| CAS Number | 935279-95-1 |
| Synonyms | 4-ethoxycarbonyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid |
| Molecular Formula | C16H17NO4 |
| Purity | ≥95% |
| IUPAC Name | 4-ethoxycarbonyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid |
| InChI | InChI=1S/C16H17NO4/c1-2-21-16(20)14-11-5-3-4-10(11)12-8-9(15(18)19)6-7-13(12)17-14/h3-4,6-8,10-11,14,17H,2,5H2,1H3,(H,18,19) |
| InChIKey | LQFSYWYGZHWLIW-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1C2CC=CC2C3=C(N1)C=CC(=C3)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
