Dalazatide TFA

• CAT Number: I042350
• Molecular Formula: C184H296N57O55PS7.xC2HF3O2
• Molecular Weight: 4442.08 (free acid)
• Purity: ≥95%

Dalazatide TFA (Cat No.: I042350) is the trifluoroacetate salt form of Dalazatide, a synthetic peptide inhibitor of the Kv1.3 potassium channel, which plays a key role in effector memory T-cell activation. By selectively blocking Kv1.3, Dalazatide modulates immune responses, making it a promising therapeutic candidate for autoimmune diseases such as psoriasis, multiple sclerosis, and lupus. The TFA salt improves peptide stability and solubility for research applications. Dalazatide TFA is valuable in immunology studies targeting T-cell-mediated inflammation and immune dysregulation.

Reference

[1]. Olsen C, et al. Dalazatide (ShK-186), a first-in-class peptide inhibitor of Kv1. 3 potassium channels, demonstrates safety, tolerability and proof of concept of efficacy in patients with active plaque psoriasis. J. Invest. Dermatol., 2016, 136(8).

[2]. Stevens A M, et al. Thu0285 Dalazatide, an Inhibitor of the KV1. 3 Channel on Activated Effector Memory T Cells, Has Immunotherapy Potential in Systemic Lupus Erythematosus. 2016.

[3]. Matheu MP, et al. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17;29(4):602-14.
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