Dagrocorat hydrochloride

• CAT Number: I008650
• CAS Number: 1044535-61-6
• Molecular Formula: C29H30ClF3N2O2
• Molecular Weight: 531.01
• Purity: ≥95%
• Synonyms: (4bS,7R,8aR)-4b-benzyl-7-hydroxy-N-(2-methylpyridin-3-yl)-7-(trifluoromethyl)-5,6,8,8a,9,10-hexahydrophenanthrene-2-carboxamide;hydrochloride
• InChI: InChI=1S/C29H29F3N2O2.ClH/c1-19-25(8-5-15-33-19)34-26(35)22-10-12-24-21(16-22)9-11-23-18-28(36,29(30,31)32)14-13-27(23,24)17-20-6-3-2-4-7-20;/h2-8,10,12,15-16,23,36H,9,11,13-14,17-18H2,1H3,(H,34,35);1H/t23-,27+,28-;/m1./s1
• InChIKey: IHLZSINDEDTWTB-KKVPRZDISA-N
• SMILES: CC1=C(C=CC=N1)NC(=O)C2=CC3=C(C=C2)[C@@]4(CC[C@@](C[C@H]4CC3)(C(F)(F)F)O)CC5=CC=CC=C5.Cl

Dagrocorat hydrochloride（Cat No.:I008650）is a non-steroidal selective glucocorticoid receptor modulator (SGRM) designed to mimic the anti-inflammatory benefits of glucocorticoids while minimizing side effects. By selectively modulating glucocorticoid receptor activity, Dagrocorat offers a targeted approach to treating chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Unlike traditional corticosteroids, it aims to reduce adverse effects like bone loss, metabolic dysfunction, and immunosuppression. Its hydrochloride salt form enhances solubility and stability. Clinical studies have shown promise in achieving therapeutic efficacy with an improved safety profile compared to standard glucocorticoids.