D75-4590（Cat No.:I025475）is a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme responsible for converting inactive cortisone to active cortisol in tissues. By blocking 11β-HSD1, D75-4590 reduces intracellular cortisol levels, offering therapeutic potential for metabolic disorders such as type 2 diabetes, obesity, and metabolic syndrome. Preclinical studies have shown that D75-4590 improves insulin sensitivity, reduces hepatic glucose production, and attenuates inflammation. Its selectivity and efficacy make it a valuable tool for exploring the role of glucocorticoid regulation in metabolic disease and for developing targeted endocrine therapies.