[D-Leu-4]-OB3

• CAT Number: I043951
• CAS Number: 289056-32-2
• Molecular Formula: C29H50N8O12S
• Molecular Weight: 734.82
• Purity: ≥95%
• Synonyms: (2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoic acid
• InChI: InChI=1S/C29H50N8O12S/c1-13(2)9-17(33-25(44)18(11-39)34-26(45)19(12-50)35-23(42)15(30)10-38)28(47)37-8-4-5-20(37)27(46)32-16(6-7-21(31)41)24(43)36-22(14(3)40)29(48)49/h13-20,22,38-40,50H,4-12,30H2,1-3H3,(H2,31,41)(H,32,46)(H,33,44)(H,34,45)(H,35,42)(H,36,43)(H,48,49)/t14-,15+,16+,17-,18+,19+,20+,22+/m1/s1
• InChIKey: UPGRZGJMOBNXSP-SRUBXKRYSA-N
• SMILES: C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)N)O

[D-Leu-4]-OB3（Cat No.:I043951）is a synthetic peptide analog of the OB3 peptide, derived from leptin, designed to retain biological activity while improving stability and bioavailability. By substituting leucine with D-leucine at position 4, [D-Leu-4]-OB3 resists enzymatic degradation, enhancing its therapeutic potential. It mimics leptin’s metabolic regulatory functions, including appetite suppression, energy expenditure, and glucose metabolism, without binding to the classical leptin receptor. This peptide is valuable in obesity and diabetes research, offering insights into alternative leptin pathways and novel treatment strategies for metabolic disorders resistant to traditional leptin-based therapies.