CZC-54252 hydrochloride

• CAT Number: I045782
• CAS Number: 1784253-05-9
• Molecular Formula: C22H26Cl2N6O4S
• Molecular Weight: 541.45
• Purity: ≥95%
• Synonyms: N-[2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide;hydrochloride
• InChI: InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
• InChIKey: KWCBHUPLQMUKAF-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl

CZC-54252 hydrochloride（Cat No.:I045782）is a potent and selective antagonist of the chemokine receptor CCR1, which regulates leukocyte trafficking, inflammation, and immune responses. By blocking CCR1-mediated signaling, this compound reduces the recruitment of monocytes and T cells to inflamed tissues, making it a valuable tool for exploring inflammatory and autoimmune disease mechanisms. CZC-54252 hydrochloride has shown promise in preclinical models of rheumatoid arthritis and multiple sclerosis. Its high specificity and favorable solubility profile support its application in immunology research, drug development, and therapeutic studies targeting chemokine-driven pathologies.