CZC-25146- CAS 1191911-26-8

CAS No.: 1191911-26-8

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CZC-25146,1191911-26-8
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000694
Synonyms:

(E)-N-(2-((5-fluoro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4(3H)-ylidene)amino)phenyl)methanesulfonamide

Molecular Formula:

C22H25FN6O4S

Molecular Weight:488.5
IC50::4.76 nM/6.87 nM(wild type/G2019S LRRK2) [1]
Description:CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.
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CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.
IC50 value: 4.76 nM/6.87 nM(wild type/G2019S LRRK2) [1]
Target: LRRK2
CZC-25146displayed a very clean profile, it inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2 and PIP4K2C) with high potency, none of which have been classified as predictors of genotoxicity or hematopoietic toxicity. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentrations below 5
μM over a seven-day treatment in culture nor did it block neuronal development in vitro. CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and a clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies.

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