CYP4A11/CYP4F2-IN-1

• CAT Number: I042578
• CAS Number: 502654-40-2
• Molecular Formula: C15H15N3OS
• Molecular Weight: 285.36
• Purity: ≥95%
• Synonyms: 4-methyl-5-[2-[4-(1H-pyrazol-5-yl)phenoxy]ethyl]-1,3-thiazole
• InChI: InChI=1S/C15H15N3OS/c1-11-15(20-10-16-11)7-9-19-13-4-2-12(3-5-13)14-6-8-17-18-14/h2-6,8,10H,7,9H2,1H3,(H,17,18)
• InChIKey: QVEFQEQVSXFMCV-UHFFFAOYSA-N
• SMILES: CC1=C(SC=N1)CCOC2=CC=C(C=C2)C3=CC=NN3

CYP4A11/CYP4F2-IN-1 (Cat No.: I042578) is a selective small-molecule inhibitor targeting the cytochrome P450 enzymes CYP4A11 and CYP4F2, which are key in fatty acid ω-hydroxylation, particularly of arachidonic acid to 20-HETE. Inhibiting these enzymes affects vascular tone, renal sodium handling, and blood pressure regulation. CYP4A11/CYP4F2-IN-1 is utilized in cardiovascular and renal research to explore the role of 20-HETE in hypertension, kidney function, and metabolic disorders. Its specificity makes it a valuable tool for studying P450 enzyme function and related signaling pathways.

Reference

[1]. Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65(21):14599-14613.
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