CYP11B2-IN-1

• CAT Number: I016880
• CAS Number: 1356479-78-1
• Molecular Formula: C18H18FN3O
• Molecular Weight: 311.35
• Purity: ≥95%
• Synonyms: 2-[5-(1-cyclopropyl-6-fluorobenzimidazol-2-yl)pyridin-3-yl]propan-2-ol
• InChI: InChI=1S/C18H18FN3O/c1-18(2,23)12-7-11(9-20-10-12)17-21-15-6-3-13(19)8-16(15)22(17)14-4-5-14/h3,6-10,14,23H,4-5H2,1-2H3
• InChIKey: OAMLIJKKGZLNHE-UHFFFAOYSA-N
• SMILES: CC(C)(C1=CN=CC(=C1)C2=NC3=C(N2C4CC4)C=C(C=C3)F)O

CYP11B2-IN-1 (CAT: I016880) is a highly potent and selective aldosterone synthase (CYP11B2) inhibitor, with an IC₅₀ of 2.3 nM. It shows >60-fold selectivity over CYP11B1 (IC₅₀ = 142 nM) and weak inhibition of CYP19 (IC₅₀ = 1021 nM). In a rhesus pharmacodynamic model, CYP11B2-IN-1 produces dose-dependent aldosterone suppression without affecting cortisol levels. Pharmacokinetic evaluation reveals low plasma clearance and favorable oral exposure. Intravenous dosing at 0.01 and 0.3 mg/kg reduced aldosterone AUC by 62% and 95%, respectively. With strong efficacy and selectivity, CYP11B2-IN-1 is a valuable lead for research in hypertension, heart failure, and aldosterone-related disorders.