For research use only. Not for therapeutic Use.
CYM50260 (CAT: I005953) is a potent and highly selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonist, exhibiting an EC₅₀ of 45 nM with no detectable activity at S1P₁, S1P₂, S1P₃, or S1P₅ receptors. As a synthetic agonist, CYM50260 is 3.5-fold more potent than the initial HTS hit compound, providing a superior tool for selective S1P₄-R modulation. Functionally, CYM50260 suppresses collagen-stimulated platelet aggregation, inhibits PDGF-AB secretion, and reduces sCD40L release. It also decreases phosphorylated-HSP27 release and attenuates HSP27 phosphorylation. CYM50260 is a valuable pharmacological probe for investigating S1P₄-R–mediated signaling, platelet function, and potential therapeutic strategies in inflammation and vascular biology.
| CAS Number | 1355026-60-6 |
| Synonyms | 2-chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine |
| Molecular Formula | C14H11Cl3FNO2 |
| Purity | ≥95% |
| IUPAC Name | 2-chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine |
| InChI | InChI=1S/C14H11Cl3FNO2/c15-9-1-3-12(11(16)7-9)20-5-6-21-13-4-2-10(8-18)19-14(13)17/h1-4,7H,5-6,8H2 |
| InChIKey | FHPOTBQOUBMMCI-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1Cl)Cl)OCCOC2=C(N=C(C=C2)CF)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
