For research use only. Not for therapeutic Use.
CYH33 Methanesulfonate（Cat No.:I044383）is a highly selective, orally bioavailable inhibitor of class I PI3Kα (phosphoinositide 3-kinase alpha), showing promise in cancer therapy. This compound effectively blocks the PI3K/AKT/mTOR signaling pathway, frequently dysregulated in solid tumors. The methanesulfonate salt form enhances its solubility and stability, making it suitable for preclinical and clinical research. CYH33 demonstrates potent antitumor activity, particularly in PI3Kα-mutant cancers, such as certain breast and ovarian carcinomas. Its selectivity reduces off-target effects, supporting its potential as a targeted therapeutic in precision oncology approaches.
| CAS Number | 1494684-33-1 |
| Synonyms | methanesulfonic acid;methyl N-[5-[6-[(4-methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylpyrrolo[2,1-f][1,2,4]triazin-2-yl]-4-(trifluoromethyl)pyridin-2-yl]carbamate |
| Molecular Formula | C25H33F3N8O8S2 |
| Purity | ≥95% |
| IUPAC Name | methanesulfonic acid;methyl N-[5-[6-[(4-methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylpyrrolo[2,1-f][1,2,4]triazin-2-yl]-4-(trifluoromethyl)pyridin-2-yl]carbamate |
| InChI | InChI=1S/C24H29F3N8O5S.CH4O3S/c1-39-23(36)29-20-12-18(24(25,26)27)17(13-28-20)21-30-22(33-7-9-40-10-8-33)19-11-16(15-35(19)31-21)14-32-3-5-34(6-4-32)41(2,37)38;1-5(2,3)4/h11-13,15H,3-10,14H2,1-2H3,(H,28,29,36);1H3,(H,2,3,4) |
| InChIKey | CYWUJTNXNJVGLY-UHFFFAOYSA-N |
| SMILES | COC(=O)NC1=NC=C(C(=C1)C(F)(F)F)C2=NN3C=C(C=C3C(=N2)N4CCOCC4)CN5CCN(CC5)S(=O)(=O)C.CS(=O)(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
