Cyclophellitol aziridine

• CAT Number: I040534
• CAS Number: 136861-97-7
• Molecular Formula: C7H13NO4
• Molecular Weight: 175.18
• Purity: ≥95%
• Synonyms: (1R,2S,3S,4R,5R,6R)-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol
• IUPAC Name: 1R,2S,3S,4R,5R,6R)-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol
• InChI: InChI=1S/C7H13NO4/c9-1-2-3-4(8-3)6(11)7(12)5(2)10/h2-12H,1H2/t2-,3+,4+,5+,6-,7-/m0/s1
• InChIKey: GPIFFOGPRPKRHS-DRYVTRLFSA-N
• SMILES: C(C1C2C(N2)C(C(C1O)O)O)O

Cyclophellitol aziridine(CAT: I040534) is a covalent, mechanism-based inhibitor derived from cyclophellitol, engineered to target and irreversibly inhibit retaining glycosidases. The incorporation of the aziridine moiety enhances its reactivity toward the nucleophilic active site of glycosidases, making it an effective probe for activity-based protein profiling (ABPP). Cyclophellitol aziridine is widely used in glycobiology and enzymology to study glycosidase function, substrate specificity, and disease-associated enzyme activity, including lysosomal storage disorders. Its covalent binding capability enables precise labeling and detection of active enzymes in complex biological samples. Supplied at high purity, this compound is ideal for biochemical assays, structural studies, and diagnostic probe development.