For research use only. Not for therapeutic Use.
Cyclo(his-pro) TFA (CAT: I017500) is an orally active cyclic dipeptide structurally related to thyrotropin-releasing hormone (TRH). It readily crosses the blood–brain barrier and exhibits anti-inflammatory and neuroprotective properties. Cyclo(his-pro) TFA inhibits NF-κB nuclear accumulation while promoting Nrf2 activation, thereby attenuating oxidative stress and inflammatory signaling. In cellular models, it reduces paraquat-induced protein nitration, cytochrome c release, and apoptosis. In vivo, Cyclo(his-pro) TFA alleviates TPA-induced ear edema and suppresses LPS-induced gliosis by modulating TNFα expression and unfolded protein response pathways. This compound is a valuable research tool for studying neuroinflammation, oxidative stress, and stress response regulation.
| CAS Number | 936749-56-3 |
| Synonyms | (3S,8aS)-3-(1H-imidazol-5-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;2,2,2-trifluoroacetic acid |
| Molecular Formula | C13H15F3N4O4 |
| Purity | ≥95% |
| IUPAC Name | (3S,8aS)-3-(1H-imidazol-5-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;2,2,2-trifluoroacetic acid |
| InChI | InChI=1S/C11H14N4O2.C2HF3O2/c16-10-9-2-1-3-15(9)11(17)8(14-10)4-7-5-12-6-13-7;3-2(4,5)1(6)7/h5-6,8-9H,1-4H2,(H,12,13)(H,14,16);(H,6,7)/t8-,9-;/m0./s1 |
| InChIKey | YOFCDSUBRJNLBB-OZZZDHQUSA-N |
| SMILES | C1CC2C(=O)NC(C(=O)N2C1)CC3=CN=CN3.C(=O)(C(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
