Cy5.5 DBCO

• CAT Number: I042588
• CAS Number: 1857352-95-4
• Molecular Formula: C59H58N4O14S4
• Molecular Weight: 1175.37
• Purity: ≥95%
• Synonyms: (2Z)-2-[(2E,4E)-5-[3-[6-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-6-oxohexyl]-1,1-dimethyl-6,8-disulfobenzo[e]indol-3-ium-2-yl]penta-2,4-dienylidene]-3-ethyl-1,1-dimethyl-8-sulfobenzo[e]indole-6-sulfonate
• InChI: InChI=1S/C59H58N4O14S4/c1-6-61-48-28-26-43-45(33-41(78(66,67)68)35-50(43)80(72,73)74)56(48)58(2,3)52(61)21-9-7-10-22-53-59(4,5)57-46-34-42(79(69,70)71)36-51(81(75,76)77)44(46)27-29-49(57)62(53)32-16-8-11-23-54(64)60-31-30-55(65)63-37-40-19-13-12-17-38(40)24-25-39-18-14-15-20-47(39)63/h7,9-10,12-15,17-22,26-29,33-36H,6,8,11,16,23,30-32,37H2,1-5H3,(H4-,60,64,66,67,68,69,70,71,72,73,74,75,76,77)
• InChIKey: VTRGNBPOXZSARU-UHFFFAOYSA-N
• SMILES: CCN1C2=C(C3=C(C=C2)C(=CC(=C3)S(=O)(=O)O)S(=O)(=O)[O-])C(C1=CC=CC=CC4=[N+](C5=C(C4(C)C)C6=C(C=C5)C(=CC(=C6)S(=O)(=O)O)S(=O)(=O)O)CCCCCC(=O)NCCC(=O)N7CC8=CC=CC=C8C#CC9=CC=CC=C97)(C)C

Cy5.5 DBCO (Cat No.: I042588) is a far-red fluorescent dye conjugated to dibenzocyclooctyne (DBCO), enabling copper-free click chemistry via strain-promoted azide-alkyne cycloaddition (SPAAC). This bioorthogonal reagent allows efficient, non-toxic labeling of azide-modified biomolecules in live cells or in vivo systems. Cy5.5 emits in the near-infrared range, offering deep tissue penetration and low background autofluorescence, ideal for imaging, tracking, and diagnostic applications. Cy5.5 DBCO is widely used in molecular biology, drug delivery studies, and targeted imaging of biomolecular interactions and cellular dynamics.

Reference

[1]. Mi Hee Choi, et al. Synthesis and evaluation of an (125)I-labeled azide prosthetic group for efficient and bioorthogonal radiolabeling of cyclooctyne-group containing molecules using copper-free click reaction. Bioorg Med Chem Lett. 2016 Feb 1;26(3):875-878.
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